The disclosure is directed to techniques for region-of-interest (ROI) processing for video telephony (VT) applications. According to the disclosed techniques, a recipient device defines ROI information for video information transmitted by a sender device, i.e., far-end video information. The recipient device transmits the ROI information to the sender device. Using the ROI information transmitted by the recipient device, the sender device applies preferential encoding to an ROI within a video scene. ROI extraction may be applied to process a user description of a region of interest (ROI) to generate information specifying the ROI based on the description. The user description may be textual, graphical, or speech-based. An extraction module applies appropriate processing to generated the ROI information from the user description. The extraction module may locally reside with a video communication device, or reside in a distinct intermediate server configured for ROI extraction.