Systems and methods are provided for handling a malicious computer-related security event that occurs at central network access points of the Internet involving networks of autonomous and different internet service providers. A system includes a non-signature based security event detection software system operating on a first computer connected to a first network of a first internet service provider, where the non-signature based security event detection software system detects the security event by examining runtime state of the first computer. A security event management software system operates on a processor-based platform and has access to security event detection results generated by the non-signature based security event detection software system.