A method for sealing the pump-out hole of vacuum glass comprises: first preparing metal layer which is bonded with the glass plate at the outside surface of the glass plate around the pump-out hole; and air-tightly welding the sealing element and the metal layer around the pump-out hole by metal brazing technology after pumping. A structure and a device for sealing the pump-out hole of vacuum glass are also provided. The method can seal the pump-out hole reliably and firmly; the sealing structure is stable and has long service life; the welding between the sealing element and the metal layer can be completed instantly and the properties of the glass materials will not be affected.