A guidewire for use in a medical procedure includes an elongate guide member dimensioned for insertion within a body vessel of a subject. The guide member includes an elongate body segment and a leading tip segment. The elongate body segment defines a longitudinal opening, and the leading tip segment is adapted and dimensioned to articulate relative to the elongate body segment about a single axis. A control element extends through the longitudinal opening of the elongate body segment and is longitudinally movable through manual manipulation of a clinician to cause corresponding articulating movement of the leading tip segment.