Invention Grant
US08986992B2 Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes
有权
通过抑制Sir2家族酶催化的酶反应来扩增干细胞/祖细胞
- Patent Title: Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes
- Patent Title (中): 通过抑制Sir2家族酶催化的酶反应来扩增干细胞/祖细胞
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Application No.: US13448705Application Date: 2012-04-17
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Publication No.: US08986992B2Publication Date: 2015-03-24
- Inventor: Tony Peled
- Applicant: Tony Peled
- Applicant Address: IL Jerusalem
- Assignee: Gamida Cell Ltd.
- Current Assignee: Gamida Cell Ltd.
- Current Assignee Address: IL Jerusalem
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Matthew Pavao
- Main IPC: C12N5/08
- IPC: C12N5/08 ; C12N5/00 ; C12N5/02 ; C12N5/0789
Abstract:
Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
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