Invention Grant
- Patent Title: Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and pharmaceutical composition comprising the same
- Patent Title (中): 包含化学交联的透明质酸衍生物和包含其的药物组合物的混合凝胶
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Application No.: US12598498Application Date: 2008-04-30
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Publication No.: US08987230B2Publication Date: 2015-03-24
- Inventor: Kazunari Akiyoshi , Nobuyuki Morimoto , Tai Hirakura , Tsuyoshi Shimoboji
- Applicant: Kazunari Akiyoshi , Nobuyuki Morimoto , Tai Hirakura , Tsuyoshi Shimoboji
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: National University Corporation Tokyo Medical and Dental University,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: National University Corporation Tokyo Medical and Dental University,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Browdy and Neimark, P.L.L.C.
- Priority: JP2007-120872 20070501
- International Application: PCT/JP2008/058593 WO 20080430
- International Announcement: WO2008/136536 WO 20081113
- Main IPC: A61K31/715
- IPC: A61K31/715 ; A61K31/728 ; A61K31/719 ; A61K31/718 ; A61K31/721 ; A61K31/722 ; A61K9/00 ; A61K9/06 ; A61K9/08 ; A61K47/36
Abstract:
The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).
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