Invention Grant
US08987268B2 Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
有权
吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途
- Patent Title: Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
- Patent Title (中): 吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途
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Application No.: US14005568Application Date: 2012-03-16
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Publication No.: US08987268B2Publication Date: 2015-03-24
- Inventor: Stephen T. Wrobleski , Jagabandhu Das , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Wu , Bingwei Vera Yang
- Applicant: Stephen T. Wrobleski , Jagabandhu Das , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Wu , Bingwei Vera Yang
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Mary VanAtten
- International Application: PCT/US2012/029366 WO 20120316
- International Announcement: WO2012/125893 WO 20120920
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D471/04 ; A01N43/58 ; A61K31/50
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
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