An interface apparatus identification system for a respiration machine such as, for example, a medical ventilator, includes a detection element which is adapted to communicate with the ventilator, a patient interface assembly including a patient interface apparatus for delivering a flow of gas from the ventilator to an airway of a patient, and a differentiating feature which is incorporated into the patient interface assembly. The patient interface apparatus is selected from a predetermined category such as, for example, a specific make or brand. The differentiating feature is detectable by the detection element to distinguish patient interface apparatus that fall within the predetermined category from those that do not. Operation of the respiration machine in conjunction with the patient interface apparatus is dependent upon detection of the differentiating feature by the detection element. An associated identification method is also disclosed.