A liquid crystal module package box includes a box body, top and bottom lids coupled to top and bottom of the box body, a cushioning retention frame received in the box body, cushioning pads arranged at two sides of the cushioning retention frame, and a support unit arranged at a central portion of the box body. The cushioning retention frame includes two lower cushioning brackets and four upper cushioning brackets corresponding to the two lower cushioning brackets. The support unit includes two support boards. When liquid crystal modules are positioned on the lower cushioning brackets, every two of the upper cushioning brackets are set on the liquid crystal modules to correspond to each one of the lower cushioning brackets. The two support boards are retained between the two lower cushioning brackets to increase central compression strength of the liquid crystal module package box at the central portion.