A plasma filter is provided for separating aggregates and targeted blood cell species from plasma comprising a filter housing with an inlet and an outlet and an internal flow path between the inlet and outlet. A filter media is disposed in the flowpath between the inlet and the outlet for filtering plasma that passes therethrough. The filter media comprises a filter configured to substantially remove targeted blood cell types from the plasma and a prefilter upstream of the filter, the prefilter having at least one reinforcement layer.