A time indicating label for attachment to a tube, the label comprising: (A) An impermeable facesheet optionally adapted to accepting a graphic before or after attachment of the label to a tube, (B) An activation layer comprising a polymer matrix and an activating agent, the activation layer in contact with the facesheet, (C) A release liner impermeable to the activating agent and in contact with the activation layer, (D) A timing layer comprising a film-forming polymer and a pigment, the timing layer in contact with the release liner, (E) A dye layer comprising a film-forming polymer and an organic solvent soluble dye and in contact with the timing layer, and (F) A base layer comprising a material impermeable to the activating agent and dye and in contact with both the dye layer and the activation layer.