Invention Grant
- Patent Title: Treatment of protein degradation disorders
- Patent Title (中): 治疗蛋白质降解障碍
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Application No.: US11386959Application Date: 2006-03-22
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Publication No.: US08999289B2Publication Date: 2015-04-07
- Inventor: Kenneth C. Anderson , James E. Bradner , Edward Franklin Greenberg , Teru Hideshima , Nicholas Paul Kwiatkowski , Ralph Mazitschek , Stuart L. Schreiber , Jared Shaw , Stephen J. Haggarty
- Applicant: Kenneth C. Anderson , James E. Bradner , Edward Franklin Greenberg , Teru Hideshima , Nicholas Paul Kwiatkowski , Ralph Mazitschek , Stuart L. Schreiber , Jared Shaw , Stephen J. Haggarty
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: President and Fellows of Harvard College,Dana-Farber Cancer Institute, Inc.
- Current Assignee: President and Fellows of Harvard College,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Agent C. Hunter Baker; Xiaohong Shou
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61K31/357 ; A61K31/35 ; A61K31/4965 ; A61K31/69 ; A61K45/06 ; A61K49/00 ; G01N33/50 ; A61K38/50
Abstract:
The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
Public/Granted literature
- US20060239909A1 Treatment of protein degradation disorders Public/Granted day:2006-10-26
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