Invention Grant
US08999335B2 Compositions and methods for treatment of drug resistant multiple myeloma
有权
用于治疗耐药性多发性骨髓瘤的组合物和方法
- Patent Title: Compositions and methods for treatment of drug resistant multiple myeloma
- Patent Title (中): 用于治疗耐药性多发性骨髓瘤的组合物和方法
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Application No.: US13821176Application Date: 2011-09-16
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Publication No.: US08999335B2Publication Date: 2015-04-07
- Inventor: Gad S. Cojocaru , Haiming Chen , James Berenson
- Applicant: Gad S. Cojocaru , Haiming Chen , James Berenson
- Applicant Address: IL Tel Aviv
- Assignee: Compugen Ltd.
- Current Assignee: Compugen Ltd.
- Current Assignee Address: IL Tel Aviv
- Agency: Graeser Associates International Inc
- Agent Dvorah Graeser
- International Application: PCT/IB2011/054060 WO 20110916
- International Announcement: WO2012/035518 WO 20120322
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; A61K31/713 ; C07K16/30 ; C12N15/113 ; G01N33/574 ; A61K45/06 ; C12Q1/68 ; G01N33/68
Abstract:
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages, wherein the cancer is relates to multiple myeloma, including multiple myeloma precursor diseases. This invention further relates to extracellular domains of TMEM154 proteins and variants, and therapeutic usages thereof.
Public/Granted literature
- US20130266510A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DRUG RESISTANT MULTIPLE MYELOMA Public/Granted day:2013-10-10
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