Invention Grant
- Patent Title: Monoclonal antibodies against Orthopoxviruses
- Patent Title (中): 针对痘病毒的单克隆抗体
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Application No.: US13742480Application Date: 2013-01-16
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Publication No.: US08999336B2Publication Date: 2015-04-07
- Inventor: Zhaochun Chen , Patricia Earl , Bernard Moss , Suzanne U. Emerson , Robert H. Purcell
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Sheridan Ross P.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K14/005 ; C07K16/08 ; G01N33/569 ; A61K39/12 ; A61K39/00
Abstract:
The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
Public/Granted literature
- US20130251704A1 MONOCLONAL ANTIBODIES AGAINST ORTHOPOXVIRUSES Public/Granted day:2013-09-26
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