Invention Grant
US08999348B2 Variants of group 6 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues
有权
由于脯氨酸残基的诱变，具有降低变应原性的真正草的6组变应原的变体
- Patent Title: Variants of group 6 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues
- Patent Title (中): 由于脯氨酸残基的诱变，具有降低变应原性的真正草的6组变应原的变体
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Application No.: US13522041Application Date: 2010-12-17
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Publication No.: US08999348B2Publication Date: 2015-04-07
- Inventor: Martin Wald , Andreas Nandy , Helmut Fiebig , Bernhard Weber , Helga Kahlert , Gerald Reese , Oliver Cromwell
- Applicant: Martin Wald , Andreas Nandy , Helmut Fiebig , Bernhard Weber , Helga Kahlert , Gerald Reese , Oliver Cromwell
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP10000293 20100114
- International Application: PCT/EP2010/007745 WO 20101217
- International Announcement: WO2011/085782 WO 20110721
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K39/00 ; A61K39/35 ; A61K39/36 ; C07K14/415 ; A61K45/06
Abstract:
The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterized by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
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