Invention Grant
- Patent Title: HMGB1-derived peptides enhance immune response to antigens
- Patent Title (中): HMGB1衍生的肽增强对抗原的免疫应答
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Application No.: US13812455Application Date: 2011-07-27
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Publication No.: US08999349B2Publication Date: 2015-04-07
- Inventor: Davorka Messmer , Rebecca Saenz
- Applicant: Davorka Messmer , Rebecca Saenz
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Adriano & Associates
- International Application: PCT/US2011/045620 WO 20110727
- International Announcement: WO2012/015979 WO 20120202
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; A61K38/10 ; A61K9/00 ; A61K39/39 ; C07K7/06 ; A61K38/08 ; A61K38/00
Abstract:
The invention provides an immunostimulatory peptide containing the amino acid sequence SAFFLFCSE and uses thereof.The invention also provides an immunostimulatory peptide containing the amino acid sequence DPNAPKRPPSAFFLX1X2X3X4 or derivatives thereof. In one embodiment, when X1 is alanine (A), glycine (G), or valine (V) then X2 is C, X3 is S and X4 is E; wherein when X2 is alanine (A), glycine (G), or valine (V) then X1 is F, X3 is S and X4 is E; wherein when X3 is alanine (A), glycine (G), or valine (V) then X1 is F, X2 is C and X4 is E; or wherein when X4 is alanine (A), glycine (G), or valine (V) then X1 is F, X2 is C and X3 is S.
Public/Granted literature
- US20130122031A1 HMGB1-DERIVED PEPTIDES ENHANCE IMMUNE RESPONSE TO ANTIGENS Public/Granted day:2013-05-16
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