Invention Grant
US08999632B2 Method for measuring ATR inhibition mediated increases in DNA damage
有权
用于测量ATR抑制的方法介导DNA损伤的增加
- Patent Title: Method for measuring ATR inhibition mediated increases in DNA damage
- Patent Title (中): 用于测量ATR抑制的方法介导DNA损伤的增加
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Application No.: US14045373Application Date: 2013-10-03
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Publication No.: US08999632B2Publication Date: 2015-04-07
- Inventor: Susanna Falcon , Philip Reaper , John Pollard , Nicola Curtin , Fiona Middleton , Tao Chen
- Applicant: Vertex Pharmaceuticals Incorporated , University of Newcastle Upon Tyne
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Rory C. Stewart
- Main IPC: A01N1/02
- IPC: A01N1/02 ; C12Q1/48 ; G01N33/50 ; G01N33/68
Abstract:
The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
Public/Granted literature
- US20140134596A1 Method for Measuring ATR Inhibition mediated increases in DNA damage Public/Granted day:2014-05-15
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