Invention Grant
- Patent Title: Method of increasing the function of an AAV vector
- Patent Title (中): 增加AAV载体功能的方法
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Application No.: US11887679Application Date: 2006-04-07
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Publication No.: US08999678B2Publication Date: 2015-04-07
- Inventor: Luk Vandenberghe , Guangping Gao , James M. Wilson
- Applicant: Luk Vandenberghe , Guangping Gao , James M. Wilson
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Howson & Howson LLP
- International Application: PCT/US2006/013375 WO 20060407
- International Announcement: WO2006/110689 WO 20061019
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61K48/00
Abstract:
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
Public/Granted literature
- US20090197338A1 Method of Increasing the Function of an AAV Vector Public/Granted day:2009-08-06
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