Invention Grant
- Patent Title: Method of making hybrid cells that express useful antibodies
- Patent Title (中): 制备表达有用抗体的杂交细胞的方法
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Application No.: US12864889Application Date: 2009-01-28
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Publication No.: US08999707B2Publication Date: 2015-04-07
- Inventor: Scott K. Dessain , Sharad P. Adekar
- Applicant: Scott K. Dessain , Sharad P. Adekar
- Applicant Address: US PA Philadelphia
- Assignee: Thomas Jefferson University
- Current Assignee: Thomas Jefferson University
- Current Assignee Address: US PA Philadelphia
- Agency: Drinker Biddle & Reath LLP
- International Application: PCT/US2009/000562 WO 20090128
- International Announcement: WO2009/105150 WO 20090827
- Main IPC: C12N5/06
- IPC: C12N5/06 ; C12N5/00 ; C07K16/12 ; C12N5/16
Abstract:
This invention relates to a novel hybridoma strategy that uses CD27+ B cells cultured in vitro to induce IgM to IgG class switch prior to fusion with a fusion partner. Hybridomas resulting from the fusion between CD27+ B cells and a fusion partner cell line and antibodies secreted from the hybridomas are included in the invention.
Public/Granted literature
- US20110002937A1 METHOD OF MAKING HYBRID CELLS THAT EXPRESS USEFUL ANTIBODIES Public/Granted day:2011-01-06
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