Invention Grant
US08999915B2 Methods for attenuating release of inflammatory mediators and peptides useful therein
有权
用于减轻其中有用的炎性介质和肽的释放的方法
- Patent Title: Methods for attenuating release of inflammatory mediators and peptides useful therein
- Patent Title (中): 用于减轻其中有用的炎性介质和肽的释放的方法
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Application No.: US12359892Application Date: 2009-01-26
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Publication No.: US08999915B2Publication Date: 2015-04-07
- Inventor: Indu Parikh
- Applicant: Indu Parikh
- Applicant Address: US NC Durham
- Assignee: Biomarck Pharmaceuticals, Ltd.
- Current Assignee: Biomarck Pharmaceuticals, Ltd.
- Current Assignee Address: US NC Durham
- Agency: Cooley LLP
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/17 ; A61K38/10
Abstract:
The present invention includes methods of inhibiting or suppressing cellular secretory processes. More specifically the present invention relates to inhibiting or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from granules in inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. Peptide fragments and variants thereof of MANS peptide as disclosed in the present invention are useful in such methods.
Public/Granted literature
- US20090203620A1 METHODS FOR ATTENUATING RELEASE OF INFLAMMATORY MEDIATORS AND PEPTIDES USEFUL THEREIN Public/Granted day:2009-08-13
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