Invention Grant
US08999919B2 Compositions and methods for inhibiting the interaction between CFTR and CAL
有权
抑制CFTR和CAL之间相互作用的组合物和方法
- Patent Title: Compositions and methods for inhibiting the interaction between CFTR and CAL
- Patent Title (中): 抑制CFTR和CAL之间相互作用的组合物和方法
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Application No.: US13292151Application Date: 2011-11-09
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Publication No.: US08999919B2Publication Date: 2015-04-07
- Inventor: Dean R. Madden , Patrick R. Cushing , Prisca Boisguearin , Rudolph Volkmer , Lars Vouilleme
- Applicant: Dean R. Madden , Patrick R. Cushing , Prisca Boisguearin , Rudolph Volkmer , Lars Vouilleme
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K38/03
- IPC: A61K38/03 ; A61K38/08 ; A61P3/00 ; C07K4/00 ; C07K7/04 ; C07K7/06 ; C07K7/08 ; A61K38/00 ; A61K38/04 ; A61K38/10 ; C07K5/103 ; C07K14/47
Abstract:
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
Public/Granted literature
- US20120071396A1 Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL Public/Granted day:2012-03-22
Information query
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