Invention Grant
US08999931B2 Pharmaceutical composition using gonadotropin-releasing hormone (GNRH) combined variants as immunogen
有权
使用促性腺激素释放激素(GNRH)联合变种作为免疫原的药物组合物
- Patent Title: Pharmaceutical composition using gonadotropin-releasing hormone (GNRH) combined variants as immunogen
- Patent Title (中): 使用促性腺激素释放激素(GNRH)联合变种作为免疫原的药物组合物
-
Application No.: US13121915Application Date: 2009-09-30
-
Publication No.: US08999931B2Publication Date: 2015-04-07
- Inventor: Jesus Arturo Junco Barranco , Osvaldo Reyes Acosta , Eddy Emilio Bover Fuentes , Franklin Fuentes Aguilar , Eulogio Pimentel Vazquez , Roberto Basulto Baker , Gerardo Enrique Guillen Nieto , Yovisleidys Lopez Saez , Hilda Elisa Garay Perez , Lesvia Calzada Aguilera , Maria Castro Santana , Niurka Oneysi Arteaga More , Luis Alberto Aguero Barrocal
- Applicant: Jesus Arturo Junco Barranco , Osvaldo Reyes Acosta , Eddy Emilio Bover Fuentes , Franklin Fuentes Aguilar , Eulogio Pimentel Vazquez , Roberto Basulto Baker , Gerardo Enrique Guillen Nieto , Yovisleidys Lopez Saez , Hilda Elisa Garay Perez , Lesvia Calzada Aguilera , Maria Castro Santana , Niurka Oneysi Arteaga More , Luis Alberto Aguero Barrocal
- Applicant Address: CU Ciudad de La Habana
- Assignee: Centro de Ingenieria Genetica y Biotecnologia
- Current Assignee: Centro de Ingenieria Genetica y Biotecnologia
- Current Assignee Address: CU Ciudad de La Habana
- Agency: Hoffmann & Baron, LLP
- Priority: CU08/0185 20080930
- International Application: PCT/CU2009/000007 WO 20090930
- International Announcement: WO2010/037352 WO 20100408
- Main IPC: A61K38/09
- IPC: A61K38/09 ; A61K47/48 ; A61K39/00

Abstract:
A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.
Public/Granted literature
- US20110250196A1 PHARMACEUTICAL COMPOSITION USING GONADOTROPIN - RELEASING HORMONE (GNRH) COMBINED VARIANTS AS IMMUNOGEN Public/Granted day:2011-10-13
Information query
IPC分类: