Invention Grant
US08999934B2 Treatment of astrocytes-tumor cells inhibitors of endothelin receptors
有权
治疗星形胶质细胞 - 肿瘤细胞内皮素受体抑制剂
- Patent Title: Treatment of astrocytes-tumor cells inhibitors of endothelin receptors
- Patent Title (中): 治疗星形胶质细胞 - 肿瘤细胞内皮素受体抑制剂
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Application No.: US13390072Application Date: 2010-08-09
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Publication No.: US08999934B2Publication Date: 2015-04-07
- Inventor: Isaiah Fidler , Sun-jin Kim
- Applicant: Isaiah Fidler , Sun-jin Kim
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Hunton & Williams LLP
- International Application: PCT/US2010/044832 WO 20100809
- International Announcement: WO2011/019630 WO 20110217
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/337 ; A01K67/027 ; A61K31/4188 ; C12N5/079 ; C12N5/09 ; G01N33/50
Abstract:
The disclosure relates to an endothelin receptor antagonist for use in the prevention or treatment of brain metastases in combination with a cytotoxic chemotherapy agent, radiotherapy or both. The endothelin receptor antagonist may for example be bosentan, macitentan or a mixture of bosentan and macitentan.
Public/Granted literature
- US20120144510A1 TREATMENT OF ASTROCYTES-TUMOR CELLS INHIBITORS OF ENDOTHELIN RECEPTORS Public/Granted day:2012-06-07
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