Invention Grant
US08999936B2 Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof
有权
可溶性淀粉样蛋白β原型原纤维特异性抗体及其用途
- Patent Title: Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof
- Patent Title (中): 可溶性淀粉样蛋白β原型原纤维特异性抗体及其用途
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Application No.: US13780643Application Date: 2013-02-28
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Publication No.: US08999936B2Publication Date: 2015-04-07
- Inventor: Pär Gellerfors , Lars Lannfelt
- Applicant: BioArctic Neuroscience AB
- Applicant Address: SE Stockholm
- Assignee: BioArctic Neuroscience AB
- Current Assignee: BioArctic Neuroscience AB
- Current Assignee Address: SE Stockholm
- Agency: Clark & Elbing LLP
- Priority: SE0401601 20040621
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A01N37/18 ; A01N61/00 ; C07K16/00 ; C07K14/47 ; C07K16/18
Abstract:
The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Aβ 42/40 protofibril comprising N-terminal truncated Aβ forms and (ii) Aβ 42/40 Arc protofibril comprising N-terminal truncated Aβ forms and (b) has no or little cross-reactivity to Aβ 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.
Public/Granted literature
- US20130236452A1 ANTIBODIES SPECIFIC FOR SOLUBLE AMYLOID BETA PEPTIDE PROTOFIBRILS AND USES THEREOF Public/Granted day:2013-09-12
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