Invention Grant
US08999944B2 Thioredoxin interacting protein (TXNIP) as regulator of vascular function
有权
硫氧还蛋白相互作用蛋白（TXNIP）作为血管功能的调节剂
- Patent Title: Thioredoxin interacting protein (TXNIP) as regulator of vascular function
- Patent Title (中): 硫氧还蛋白相互作用蛋白（TXNIP）作为血管功能的调节剂
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Application No.: US11814442Application Date: 2006-01-20
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Publication No.: US08999944B2Publication Date: 2015-04-07
- Inventor: Bradford C. Berk
- Applicant: Bradford C. Berk
- Applicant Address: US NY Rochester
- Assignee: University of Rochester
- Current Assignee: University of Rochester
- Current Assignee Address: US NY Rochester
- Agency: LeClairRyan, a Professional Corporation
- International Application: PCT/US2006/001954 WO 20060120
- International Announcement: WO2006/078853 WO 20060727
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; G01N33/68
Abstract:
The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro-inflammatory activity of the TNF-ASK1-JNK-p38 pathways.
Public/Granted literature
- US20110097317A1 Thioredoxin Interacting Protein (TXNIP) As Regulator Of Vascular Function Public/Granted day:2011-04-28
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