Invention Grant
- Patent Title: Administration of an anti-obesity compound to individuals with renal impairment
- Patent Title (中): 向患有肾损伤的个体施用抗肥胖化合物
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Application No.: US13511639Application Date: 2011-08-31
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Publication No.: US08999970B2Publication Date: 2015-04-07
- Inventor: Christen M. Anderson , William R. Shanahan
- Applicant: Christen M. Anderson , William R. Shanahan
- Applicant Address: US CA San Diego
- Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- International Application: PCT/US2011/049936 WO 20110831
- International Announcement: WO2012/030939 WO 20120308
- Main IPC: A61K31/55
- IPC: A61K31/55 ; G01N33/70

Abstract:
The present disclosure relates to methods for weight management in an individual in need thereof by determining the level of renal sufficiency of the individual and prescribing or administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual, provided that the individual has a level of renal sufficiency selected from the group consisting of: no renal impairment, mild renal impairment, and moderate renal impairment. In addition, the disclosure relates to a method for selecting an individual for treatment with (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof from a plurality of individuals in need of weight management by determining the level of renal sufficiency of the individual and selecting the individual for treatment with (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof if the individual has a level of renal sufficiency selected from the group consisting of: no renal impairment, mild renal impairment, and moderate renal impairment.
Public/Granted literature
- US20120252787A1 ADMINISTRATION OF AN ANTI-OBESITY COMPOUND TO INDIVIDUALS WITH RENAL IMPAIRMENT Public/Granted day:2012-10-04
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