Invention Grant
US08999987B2 Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
有权
聚（ADP-核糖）聚合酶（PARP）的二氢吡喃并酞嗪酮抑制剂
- Patent Title: Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
- Patent Title (中): 聚（ADP-核糖）聚合酶（PARP）的二氢吡喃并酞嗪酮抑制剂
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Application No.: US13787496Application Date: 2013-03-06
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Publication No.: US08999987B2Publication Date: 2015-04-07
- Inventor: Bing Wang , Daniel Chu
- Applicant: BioMarin Pharmaceutical Inc.
- Applicant Address: US CA Novato
- Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee Address: US CA Novato
- Agency: Jones Day
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A61K31/495 ; C07D237/36 ; A61K31/5025 ; A61K31/5377 ; C07D471/06
Abstract:
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Public/Granted literature
- US20130190306A1 DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) Public/Granted day:2013-07-25
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