Invention Grant
US09000007B2 5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis
有权
5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物作为用于治疗动脉粥样硬化的胆固醇酯转移蛋白（CETP）抑制剂
![5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis](/docs/US/2015-04-07/US09000007B2/abs.jpg.600x600.jpg)
- Patent Title: 5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis
- Patent Title (中): 5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物作为用于治疗动脉粥样硬化的胆固醇酯转移蛋白（CETP）抑制剂
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Application No.: US14347519Application Date: 2012-09-27
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Publication No.: US09000007B2Publication Date: 2015-04-07
- Inventor: Anima Boruah , Shanavas Alikunju
- Applicant: Dr. Reddy's Laboratories, Ltd.
- Applicant Address: IN Hyderabad
- Assignee: Dr. Reddy's Laboratories Ltd.
- Current Assignee: Dr. Reddy's Laboratories Ltd.
- Current Assignee Address: IN Hyderabad
- Agency: Pergament Gilman & Cepeda LLP
- Agent Milagros A. Cepeda; Edward D. Pergament
- Priority: IN3337/CHE/2011 20110927
- International Application: PCT/IB2012/002435 WO 20120927
- International Announcement: WO2013/046045 WO 20130404
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/437 ; C07D471/04
![5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis](/abs-image/US/2015/04/07/US09000007B2/abs.jpg.150x150.jpg)
Abstract:
The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Raa, Rb and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.
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