Invention Grant
US09000030B2 Neuronal circuit-dependent neuroprotection by interaction between nicotinic receptors
有权
神经元电路依赖性神经保护通过烟碱受体之间的相互作用
- Patent Title: Neuronal circuit-dependent neuroprotection by interaction between nicotinic receptors
- Patent Title (中): 神经元电路依赖性神经保护通过烟碱受体之间的相互作用
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Application No.: US13673479Application Date: 2012-11-09
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Publication No.: US09000030B2Publication Date: 2015-04-07
- Inventor: Peter Andrew Ferchmin , Vesna Ana Eterovic De Ferchmin , Hector Manuel Maldonado , Khalid El Sayed
- Applicant: Peter Andrew Ferchmin , Vesna Ana Eterovic De Ferchmin , Hector Manuel Maldonado , Khalid El Sayed
- Agency: Harbin & Hein PLLC
- Main IPC: A61K31/382
- IPC: A61K31/382 ; A61K31/336 ; A61K31/122 ; A61K31/047 ; A61K31/045 ; A61K31/215 ; A61K31/343 ; A61K31/365 ; A61K31/366 ; A61K31/415 ; A61K31/4155 ; A61K31/439
Abstract:
A method of inhibiting excitotoxicity by indirectly activating α4β2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed Inhibitors of α7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate α4β2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.
Public/Granted literature
- US20130165495A1 NEURONAL CIRCUIT-DEPENDENT NEUROPROTECTION BY INTERACTION BETWEEN NICOTINIC RECEPTORS Public/Granted day:2013-06-27
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