Invention Grant
US09000137B2 Nucleic acid aptamers against plasmodium lactate dehydrogenase and histidine-rich protein II and uses thereof for malaria diagnosis
有权
针对乳酸脱氢酶和组氨酸富含蛋白II的核酸适配体及其用于疟疾诊断的用途
- Patent Title: Nucleic acid aptamers against plasmodium lactate dehydrogenase and histidine-rich protein II and uses thereof for malaria diagnosis
- Patent Title (中): 针对乳酸脱氢酶和组氨酸富含蛋白II的核酸适配体及其用于疟疾诊断的用途
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Application No.: US13763051Application Date: 2013-02-08
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Publication No.: US09000137B2Publication Date: 2015-04-07
- Inventor: Julian A Tanner , Yee Wai Cheung , Masayo Kotaka
- Applicant: The University of Hong Kong
- Applicant Address: CN Hong Kong
- Assignee: The University of Hong Kong
- Current Assignee: The University of Hong Kong
- Current Assignee Address: CN Hong Kong
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12Q1/68 ; G01N33/53 ; G01N33/569
Abstract:
The present invention provides nucleic acid aptamers that bind to Plasmodium proteins lactate dehydrogenase and histidine-rich protein II, and uses thereof for the diagnosis of malaria. Aptamers against histidine-rich protein II may be used to detect the presence of Plasmodium species in general, whereas aptamers against lactate dehydrogenase can be used to specifically detect Plasmodium falciparum.
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