Invention Grant
- Patent Title: Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use
- Patent Title (中): 黄病毒包膜糖蛋白交叉反应性表位的定位和表征及其使用方法
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Application No.: US12892714Application Date: 2010-09-28
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Publication No.: US09000141B2Publication Date: 2015-04-07
- Inventor: Gwong-Jen J. Chang , Wayne D. Crill
- Applicant: Gwong-Jen J. Chang , Wayne D. Crill
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07H21/00
- IPC: C07H21/00 ; A61K39/12 ; C07K14/005 ; A61K39/00
Abstract:
Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detect a flaviviral infection.
Public/Granted literature
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