Invention Grant
US09000158B2 Process for preparing levosimendan and intermediates for use in the process
有权
制备用于该过程的左西孟旦和中间体的方法
- Patent Title: Process for preparing levosimendan and intermediates for use in the process
- Patent Title (中): 制备用于该过程的左西孟旦和中间体的方法
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Application No.: US13384211Application Date: 2010-07-12
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Publication No.: US09000158B2Publication Date: 2015-04-07
- Inventor: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Manjinder Singh Phull , Ashwini Amol Sawant
- Applicant: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Manjinder Singh Phull , Ashwini Amol Sawant
- Applicant Address: IN Mumbai
- Assignee: Cipla Limited
- Current Assignee: Cipla Limited
- Current Assignee Address: IN Mumbai
- Agency: Conley Rose, P.C.
- Agent Rodney B. Carroll
- Priority: IN1645/MUM/2009 20090714
- International Application: PCT/GB2010/001325 WO 20100712
- International Announcement: WO2011/007123 WO 20110120
- Main IPC: C07D237/14
- IPC: C07D237/14 ; C07D237/04
Abstract:
In an embodiment, the present invention provides a process for preparing (−)-6-(4-aminophenyl)-5-methylpyridazin-3-(2H)-one, which process comprises: a) reacting racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone of formula II with a chiral tartaric acid derivative to obtain a diastereomeric salt of (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone and the chiral tartaric acid derivative; and b) reacting the diastereomeric salt with a base to obtain (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone. The (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone may be used to prepare levosimendan.
Public/Granted literature
- US20120165524A1 Process for Preparing Levosimendan and Intermediates for Use in the Process Public/Granted day:2012-06-28
Information query
