Invention Grant
- Patent Title: 3-amino-pyrazole derivatives useful against tuberculosis
- Patent Title (中): 可用于结核病的3-氨基 - 吡唑衍生物
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Application No.: US14295589Application Date: 2014-06-04
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Publication No.: US09000181B2Publication Date: 2015-04-07
- Inventor: Raquel Fernandez Menendez , Silvia Gonzalez Del Valle
- Applicant: Glaxo Group Limited
- Applicant Address: GB Brentford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Robert H. Brink
- Priority: EP10382266 20101013
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D277/10 ; C07D471/04 ; C07D417/14

Abstract:
A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3 alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
Public/Granted literature
- US20140288133A1 3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS Public/Granted day:2014-09-25
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