Invention Grant
US09000222B2 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
有权
（1E，6E）-1,7-双 - （3,4-二甲氧基苯基）-4,4-二取代 - 七-1,6-二烯-3,5-二酮结构支架的化合物，它们的生物活性和用途 其中
- Patent Title: Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
- Patent Title (中): （1E，6E）-1,7-双 - （3,4-二甲氧基苯基）-4,4-二取代 - 七-1,6-二烯-3,5-二酮结构支架的化合物，它们的生物活性和用途 其中
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Application No.: US13920199Application Date: 2013-06-18
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Publication No.: US09000222B2Publication Date: 2015-04-07
- Inventor: Charles Shih , Qian Shi , Hui-Kang Wang
- Applicant: Charles Shih , Qian Shi , Hui-Kang Wang
- Applicant Address: US CA San Diego
- Assignee: Androscience Corporation
- Current Assignee: Androscience Corporation
- Current Assignee Address: US CA San Diego
- Agency: David R. Preston & Associates
- Agent David R. Preston
- Main IPC: C07C49/00
- IPC: C07C49/00 ; C07C69/618 ; C07D295/192 ; A61K31/12 ; C07C309/65 ; C07D277/46 ; C07C235/78 ; C07C49/255 ; A61K31/165 ; A61K31/426 ; A61K31/5375
Abstract:
The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.
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