Invention Grant
US09000257B2 Fumarylacetoacetate hydrolase (fah)-deficient pigs and uses thereof
有权
富马酸乙酰水解酶（fah）缺乏猪及其用途
- Patent Title: Fumarylacetoacetate hydrolase (fah)-deficient pigs and uses thereof
- Patent Title (中): 富马酸乙酰水解酶（fah）缺乏猪及其用途
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Application No.: US13642213Application Date: 2011-03-23
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Publication No.: US09000257B2Publication Date: 2015-04-07
- Inventor: Markus Grompe , Scott Nyberg , Joseph Lillegard , Raymond Hickey
- Applicant: Markus Grompe , Scott Nyberg , Joseph Lillegard , Raymond Hickey
- Applicant Address: US OR Portland US MN Rochester
- Assignee: Oregon Health & Science University,Mayo Foundation for Medical Education and Research
- Current Assignee: Oregon Health & Science University,Mayo Foundation for Medical Education and Research
- Current Assignee Address: US OR Portland US MN Rochester
- Agency: Klarquist Sparkman, LLP
- Priority: JP2010-212896 20100922
- International Application: PCT/US2011/029659 WO 20110323
- International Announcement: WO2011/133284 WO 20111027
- Main IPC: C12N5/071
- IPC: C12N5/071 ; G01N33/50 ; A01K67/027 ; A61K49/00 ; C12N15/861
Abstract:
Described herein is the generation of Fah+/− heterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fah−/− homozygote pigs. The Fah-deficient pigs of the disclosure can be used for a variety of research and therapeutic purposes, such as for the expansion of human hepatocytes, and as large animal models of hereditary tyrosinemia type 1, cirrhosis and hepatocellular carcinoma.
Public/Granted literature
- US20130191931A1 FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT PIGS AND USES THEREOF Public/Granted day:2013-07-25
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