A method, computer system, and computer memory medium optimizing a transductive model Mx suitable for use in data analysis and for determining a prognostic outcome specific to a particular subject are disclosed. The particular subject may be represented by an input vector, which includes a number of variable features in relation to a scenario of interest. Samples from a global dataset D also having the same features relating to the scenario and for which the outcome is known are determined. In an embodiment, a subset of the variable features within a neighborhood formed by the samples are ranked in order of importance to an outcome. The prognostic transductive model is then created based, at least in part, on the subset, the ranking, and the neighborhood. The subset and the neighborhood are then optimized until the accuracy of the transductive model is maximized.