Administration of virtual machine affinity in a data center, where the data center includes a plurality of virtual machines (‘VMs’), each VM being a module of automated computing machinery installed upon a computer in the data center and characterized by a Universally Unique Identifier (‘UUID’), at least two of the VMs having an affinity requirement to be installed on separate computers, the data center further including a data center administration server operably coupled to the VMs, including communicating, by at least one of the VMs having an affinity requirement to the data center administration server, the UUIDs of the VMs having an affinity requirement; and moving by the data center administration server the VMs having an affinity requirement to separate computers in the data center.