Certain example embodiments relate to a framework that helps address dynamic scalability and in-order processing of payloads, e.g., pertaining to B2B and/or other transactions. A receiver and/or sender is/are able to dynamically and/or statically provide an executable to an intermediary entity (e.g., a central payload processor or CPP) to process and/or otherwise transform payloads, en-route. This arrangement advantageously provides a very efficient way of delivering ordered content, especially when the content is extremely large. Cloud processing and/or storage facilities may be implemented in certain example instances, parallel sending and/or receiving may be provided, etc., in addressing issues relating to how to send large amounts of data over large distances to possibly multiple recipients.