A data storage system configured to manage unreliable memory units is disclosed. In one embodiment, the data storage system maintains an unreliable memory unit list designating memory units in a non-volatile memory array as reliable or unreliable. The unreliable memory unit list facilitates management of unreliable memory at a granularity level finer than the granularity of a block of memory. The data storage system can add entries to the unreliable memory unit list as unreliable memory units are discovered. Further, the data storage system can continue to perform memory access operations directed to reliable memory units in blocks containing other memory units determined to be unreliable. As a result, the operational life of the data storage system is extended.