In one embodiment, a mechanism for interleaved parallel cyclic redundancy check calculation for memory devices is disclosed. In one embodiment, a method includes generating an index value as part of a cyclic redundancy check (CRC) operation, the index value being a result of a first exclusive-or operation applied to both of input data directly as-is from a data bus and to data in a 64-bit accumulator utilized to store results of the CRC operation. The method also includes indexing an interleaved parallel CRC table with the index value to retrieve a 64-bit polynomial entry from the CRC table, performing a second exclusive-or operation on the retrieved polynomial entry and data in the 64-bit accumulator, storing the results of the second exclusive-or operation in the 64-bit accumulator, and transmitting contents of the 64-bit accumulator directly as-is to the data bus.