In certain embodiments, a computer-implemented method comprises receiving, via a computer network and from a first computer system, a first malware analysis request. The first malware analysis request comprises a file to be analyzed for malware by a malware analysis system. The method includes initiating a malware analysis by the malware analysis system of the first file for malware. The method includes communicating to the first computer system a response for the first file determined by the malware analysis system to the first computer system. The response comprises an indication of whether the first file comprises malware.