Embodiments of the present disclosure are directed to oral care devices, system and methods for advanced ionic micro-current control. In some embodiments, an oral care device is actuated upon completion of an electric circuit by a users hand and oral cavity. The electrode on an oral care implement may be configured to lose conductivity over time to indicate a replacement oral care implement is need. In some embodiments, a controller of the oral care device may detect the type of oral care implement and control the ionic micro-current accordingly. Additionally, embodiments may detect a region within the oral cavity that the oral care device is in contact with and apply the ionic micro-current accordingly. Further, in some embodiments, the health status of various regions of a user's oral cavity may be detected and monitored over time.