A protective enclosure for a touch screen device, the enclosure formed of a substantially rigid tray having a rim surrounding an interior device seating surface; a lid having a substantially rigid rim surrounding a window aperture, the rim of the lid corresponding to the rim of the tray; a pliable membrane having an interior window portion that is structured for viewing there through and is sized to project outwardly of the rim surrounding the window aperture of the lid; a continuous pliable seal adapted to be compressible between the rim of the lid and the rim of the tray; and a clamping mechanism structured for clamping the rim of the lid and the rim of the tray with the pliable seal forming a continuous substantially water-resistant seal therebetween.