A nasogastric/orogastric (Ng/Og) airway protection device includes an elongate device body having a distal end for insertion into the stomach through the esophagus and a proximal end. A main lumen extends the length of the device and is configured for at least one of gastric decompression, enteral feeding and enteral medication administration. A sump port is at the distal end. A sump lumen is formed the length of the device body and configured for venting gas and preventing adherence of the device against the gastric wall. An inflatable esophageal cuff is carried by the device body mid-esophagus and an inflation lumen is formed within the device body and connects the inflatable esophageal cuff through which the esophageal cuff is inflated and deflated. Upon inflation of the esophageal cuff, emesis and/or reflux is blocked from passing out of the stomach past the esophageal cuff positioned mid-esophagus to protect a patient's airway.