Methods, devices, and systems are disclosed that help to restore lymphatic flow associated with a subcutaneous defect in a patient's body by approximating portions of the subcutaneous defect using reduced pressure and a tissue-approximating device. The tissue approximating device may include a curved member that is formed from a semi-rigid material and defines a concave space that goes over the subcutaneous defect. A flange portion is formed on the curved member. A reduced-pressure aperture is formed on the curved member for providing reduced pressure to the concave space. The tissue-approximating device also includes a spacer member disposed on a tissue-facing side of the curved member and aligned substantially with the reduced-pressure aperture. Other systems, devices, and methods are disclosed.