Invention Grant
US09011840B2 Activated mesenchymal stem cells for wound healing and impaired tissue regeneration
有权
活化的间充质干细胞用于伤口愈合和受损的组织再生
- Patent Title: Activated mesenchymal stem cells for wound healing and impaired tissue regeneration
- Patent Title (中): 活化的间充质干细胞用于伤口愈合和受损的组织再生
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Application No.: US13483910Application Date: 2012-05-30
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Publication No.: US09011840B2Publication Date: 2015-04-21
- Inventor: Amelia Bartholomew , Simon Lee , Erzsebet Szilagyi
- Applicant: Amelia Bartholomew , Simon Lee , Erzsebet Szilagyi
- Applicant Address: US IL Urbana
- Assignee: The Board of Trustees of the University of Illinois
- Current Assignee: The Board of Trustees of the University of Illinois
- Current Assignee Address: US IL Urbana
- Agency: Barnes & Thornburg LLP
- Agent Alice O. Martin
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N5/00 ; C12N5/02 ; C12N5/0775 ; A61K35/28
Abstract:
Inflammatory cytokines e.g. IFN-γ, serve as initiating stimuli for mesenchymal stem cell (MSC) immunosuppresive activity in vivo. Other inflammatory cytokines, such as TNF alpha, the molecule hemoxygenase I, and TLR ligation of MSC, may also provide such a response. Activated MSC's promote tissue regeneration in conditions such as aging, where regeneration is impaired. Wound healing in aged mammals was enhanced by restoring tensile strength to the levels of younger mammals. Activated MSCs were useful in treating wounds in diabetic primates.
Public/Granted literature
- US20130017175A1 ACTIVATED MESENCHYMAL STEM CELLS FOR WOUND HEALING AND IMPAIRED TISSUE REGENERATION Public/Granted day:2013-01-17
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