Invention Grant
US09011864B2 Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
有权
降低细胞毒性副作用并提高免疫缀合物功效的方法
- Patent Title: Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
- Patent Title (中): 降低细胞毒性副作用并提高免疫缀合物功效的方法
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Application No.: US12342180Application Date: 2008-12-23
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Publication No.: US09011864B2Publication Date: 2015-04-21
- Inventor: Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
- Applicant: Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
- Applicant Address: DE Dreieich US MA Waltham
- Assignee: Biotest AG,Immunogen, Inc.
- Current Assignee: Biotest AG,Immunogen, Inc.
- Current Assignee Address: DE Dreieich US MA Waltham
- Agency: Agris & von Natzmer LLP
- Agent Joyce von Natzmer
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; A61K47/48 ; C07K16/28 ; B82Y5/00
Abstract:
Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
Public/Granted literature
- US20090181038A1 METHOD OF DECREASING CYTOTOXIC SIDE-EFFECTS AND IMPROVING EFFICACY OF IMMUNOCONJUGATES Public/Granted day:2009-07-16
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