Invention Grant
US09011866B2 RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines
有权
阻断促凋亡蛋白表达的RNA干扰增强由DNA和转染的树突细胞疫苗诱导的免疫
- Patent Title: RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines
- Patent Title (中): 阻断促凋亡蛋白表达的RNA干扰增强由DNA和转染的树突细胞疫苗诱导的免疫
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Application No.: US11773162Application Date: 2007-07-03
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Publication No.: US09011866B2Publication Date: 2015-04-21
- Inventor: Tzyy-Choou Wu , Chien-Fu Hung
- Applicant: Tzyy-Choou Wu , Chien-Fu Hung
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Foley Hoag LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07H21/04 ; C12N15/11 ; A61K31/7088 ; C12N15/113
Abstract:
An immunotherapeutic strategy is disclosed that combines antigen-encoding DNA vaccine compositions combined with siRNA directed to pro-apoptotic genes, primarily Bak and Bax, the products of which are known to lead to apoptotic death. Gene gun delivery (particle bombardment) of siRNA specific for Bak and/or Bax to antigen-expressing DCs prolongs the lives of such DCs and lead to enhanced generation of antigen-specific CD8+ T cell-mediated immune responses in vivo. Similarly, antigen-loaded DC's transfected with siRNA targeting Bak and/or Bax serve as improved immunogens and tumor immunotherapeutic agents.
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