Invention Grant
- Patent Title: Bifunctional protein anchors
- Patent Title (中): 双功能蛋白锚点
-
Application No.: US11989118Application Date: 2006-07-20
-
Publication No.: US09011870B2Publication Date: 2015-04-21
- Inventor: Cornelis Johannes Leenhouts , Maarten Leonardus Van Roosmalen , Tjibbe Bosma
- Applicant: Cornelis Johannes Leenhouts , Maarten Leonardus Van Roosmalen , Tjibbe Bosma
- Applicant Address: NL Groningen
- Assignee: Applied Nanosystems B.V.
- Current Assignee: Applied Nanosystems B.V.
- Current Assignee Address: NL Groningen
- Agency: TraskBritt, P.C.
- Priority: EP050766880 20050720
- International Application: PCT/NL2006/000382 WO 20060720
- International Announcement: WO2007/011216 WO 20070125
- Main IPC: A61K39/385
- IPC: A61K39/385 ; C07K14/335 ; A61K39/00

Abstract:
The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
Public/Granted literature
- US20090263414A1 Bifunctional Protein Anchors Public/Granted day:2009-10-22
Information query