Invention Grant
US09011882B2 Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
有权
二甲基精氨酸二甲基氨基水解酶抑制剂及其使用方法
- Patent Title: Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
- Patent Title (中): 二甲基精氨酸二甲基氨基水解酶抑制剂及其使用方法
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Application No.: US13766336Application Date: 2013-02-13
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Publication No.: US09011882B2Publication Date: 2015-04-21
- Inventor: Yohannes T. Ghebremariam , John P. Cooke
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis, LLP
- Agent Paula A. Borden
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/542 ; A61K31/4439 ; A61K31/437 ; A61K31/428 ; A61M11/04 ; A61M15/00 ; A61M16/14 ; A61K31/444
Abstract:
The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.
Public/Granted literature
- US20130224259A1 Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof Public/Granted day:2013-08-29
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